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1.Takeda K, Yamashita T, Takahashi A, Timberlake CF.: Stable blue complexes of anthocyanin-aluminium-3-p-coumaroyl- or 3-caffeoyl-quinic acid involved in the bluing of Hydrangea flower. Phytochemistry. 29: 1089-1091, 1990.


2.Takahashi A, Takeda K, Ohnishi T.: Light-induced anthocyanin reduces the extent of damage to DNA in UV-irradiated Centaurea cyanus cells in culture. Plant Cell Phys. 32: 541-547, 1991.


3.Muramatsu T, Yamashina Y, Tada H, Kobayashi N, Yamaji M, Ohno H, Shirai T, Takahashi A, Ohnishi T.: 8-methoxypsoralen plus UVA induces the 72 kDa heat shock protein in organ-cultured normal human skin. Photochem Photobiol. 58: 809-812, 1993.


4.Ohnishi T, Matsumoto H, Takahashi A, Shimura M, Majima H.: Accumulation of mutant p53 and hsp72 by heat treatment, and their association in a human glioblastoma cell line. Int J Hyperthermia. 11: 663-671, 1995.


5.Ohnishi T, Wang X, Ohnishi K, Matsumoto H, Takahashi A.: p53-dependent induction of WAF1 by heat treatment in human glioblastoma cells. J Biol Chem. 271: 14510-14513, 1996.


6.Wang X, Matsumoto H, Takahashi A, Nakano T, Okaichi K, Ihara M, Ohnishi T.: p53 accumulation in the organs of low-dose X-ray- irradiated mice. Cancer Lett. 104: 79-84, 1996.


7.Muramatsu T, Ohno H, Shirai T, Takahashi A, Ohnishi T.: DNA-damaging agents induce the 72-kD heat shock protein in SV40 transformed normal human fibroblasts. J Dermatol. 23: 589-593, 1996.


8.Ohnishi K, Matsumoto H, Takahashi A, Wang X, Ohnishi T.: Heat shock transcription factor, HSF, is activated by ultraviolet irradiation. Photochem Photobiol. 64: 949-952, 1996.


9.Ohnishi K, Takahashi A, Tanaka H, Ohnishi T.: Relationship between frequency of upside-down posture and space size around upside-down catfish, Synodontis nigriventris. Biol Sci Space. 10: 247-251, 1996.


10.Ohnishi K, Takahashi A, Koyama M, Ohnishi T.: Postural control under clinorotation in upside-down catfish, Synodontis nigriventris. Biol Sci Space. 10: 252-258, 1996.


11.Ohnishi T, Takahashi A, Okaichi K, Ohnishi K, Matsumoto H, Takahashi S, Yamanaka H, Nakano T, Nagaoka S.: Cell growth and morphology of Dictyostelium discoideum in space environment. Biol Sci Space. 11: 29-34, 1997.


12.Takahashi A, Ohnishi K, Takahashi S, Nakano T, Nagaoka S, Ohnishi T.: Mutation frequency of Dictyostelium discoideum spores exposed to the space environment. Biol Sci Space. 11: 81-86, 1997.


13.Matsumoto H, Wang X, Takahashi A, Ohnishi T.: Induction of cdk2 after -ray irradiation is dependent on p53 status. Int J Oncol. 10: 1257-1260, 1997.


14.Matsumoto H, Takahashi A, Wang X, Ohnishi K, Ohnishi T.: Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress. Int J Radiat Oncol Biol Phys. 38: 1089-1095, 1997.


15.Ohtsubo T, Wang X, Takahashi A, Ohnishi K, Saito H, Song CW, Ohnishi T.: p53-dependent induction of WAF1 by low pH culture condition in human glioblastoma cells. Cancer Res. 57: 3910-3913, 1997.


16.Wang X, Takahashi A, Ohnishi K, Matsumoto H, Suda H, Ohnishi T.: Bifunctional effects of a protein kinase inhibitor (H-7) on heat-induced p53-dependent WAF1 accumulation. Exp Cell Res. 237: 186-191, 1997.


17.Takahashi A, Yano T, Matsumoto H, Wang X, Ohnishi K, Tamamoto T, Tsuji K, Yukawa O, Ohnishi T.: Effects of accelerated carbon-ions on growth inhibition of transplantable human esophageal cancer in nude mice. Cancer Lett. 122: 181-186, 1998.


18.Ohnishi K, Wang X, Takahashi A, Ohnishi T.: Contribution of protein kinase C to p53-dependent WAF1 induction pathway after heat treatment in human glioblastoma cell lines. Exp Cell Res. 238: 399-406, 1998.


19.Ohnishi T, Wang X, Ohnishi K, Takahashi A.: p53-dependent induction of WAF1 by cold shock in human glioblastoma cells. Oncogene. 16: 1507-1511, 1998.


20.Aoki H, Ohnishi K, Wang X, Takahashi A, Ohnishi T, Nakamura M, Sakaki T.: p53-independent WAF1 induction by ACNU in human glioblastoma cells. Mol Carcinogenesis. 21: 171-176, 1998.


21.Ohnishi T, Takahashi A, Yano T, Matsumoto H, Wang X, Ohnishi K, Tamamoto T, Tsuji K, Furusawa Y, Yukawa O.: Hyperthermic enhancement of tumor growth inhibition by accelerated carbon-ions in transplantable human esophageal cancer. Int J Hyperthermia. 14: 195-202, 1998.


22.Ohnishi K, Wang X, Takahashi A, Matsumoto H, Aoki H, Ohnishi T.: Effects of protein kinase inhibitors on heat-induced hsp72 gene expression in a human glioblastoma cell line. Cell Signal. 10: 259-264, 1998.


23.Ohnishi T, Tsuji K, Ohmura T, Matsumoto H, Wang X, Takahashi A, Nagaoka S, Takabayashi T.: Accumulation of stress protein 72 (hsp72) in muscle and spleen of goldfish taken into space. Adv Space Res. 21: 1077-1080, 1998.


24.Wang X, Ohnishi K, Takahashi A, Ohnishi T.: Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation. Oncogene. 17: 2819-2825, 1998.


25.Ohnishi T, Wang X, Takahashi A, Ohnishi K, Ejima Y.: Low-dose-rate radiation attenuates the response of the tumor suppressor TP53. Radiat Res. 151: 368-372, 1999.


26.Ohnishi T, Ohnishi K, Wang X, Takahashi A, Okaichi K.: Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone. Radiat Res. 151: 498-500, 1999.


27.Nagaoka S, Nakano T, Endo S, Onizuka T, Kagawa Y, Fujitaka K, Ohnishi K, Takahashi A, Ohnishi T.: Detection of DNA damages and repair in human culture cells with simulated space radiation. Acta Astronaut. 44: 561-567, 1999.


28.Tamamoto T, Ohnishi K, Takahashi A, Wang X, Yoshimura H, Ohishi H, Uchida H, Ohnishi T.: Correlation between gamma-ray-induced G2 arrest and radioresistance in two human cancer cells. Int J Radiat Oncol Biol Phys. 44: 905-909, 1999.


29.Ohnishi K, Wang X, Takahashi A, Matsumoto H, Ohnishi T.: The protein kinase inhibitor, H-7, suppresses heat induced activation of heat shock transcription factor 1. Mol Cell Biochem. 197: 129-135, 1999.


30.Ohnishi K, Yamamoto T, Takahashi A, Tanaka T, Koyama M, Ohnishi T.: The effect of labyrinthectomy on postural control of upside-down swimming catfish, Synodontis nigriventris under pseudomicrogravity. Phys Behavior. 67: 89-93, 1999.


31.Ostapenko VV, Wang X, Ohnishi K, Takahashi A, Yamamoto I, Tanaka Y, Ohnishi T.: Increased resistance of the radiosensitive M10 mutant cells of the L5178Y mouse lymphoma cell line to heat-induced apoptosis. Radiat Res. 152: 321-327, 1999.


32.Ohnishi T, Matsumoto H, Wang X, Takahashi A, Tamamoto T, Ohnishi K.: Restoration by glycerol of p53-dependent apoptosis in the cells bearing the mutant p53 gene. Int J Radiat Biol. 75: 1095-1098, 1999.


33.Fujino M, Ohnishi K, Asahi M, Wang X, Takahashi A, Ohnishi T.: Effects of protein kinase inhibitors on radiation-induced WAF1 accumulation in human cultured melanoma cells. Br J Dermatol. 141: 647-651, 1999.


34.Ohnishi T, Takahashi A, Wang X, Ohnishi K, Ohhira Y, Nagaoka S.: Accumulation of a tumor suppressor p53 protein in rat muscle during a space flight. Mutat Res (Fund Mol Mech Mutag). 430: 271-274, 1999.


35.Takahashi A, Ohnishi K, Tsuji K, Matsumoto H, Aoki H, Wang X, Tamamoto T, Yukawa O, Furusawa Y, Ejima Y, Tachibana A, Ohnishi T.: WAF1 accumulation by carbon-ion beam and α-particle irradiation in human glioblastoma cultured cells. Int J Radiat Biol. 76: 335-341, 2000.


36.Takahashi A, Ohnishi K, Wang X, Kobayashi M, Matsumoto H, Tamamoto T, Aoki H, Furusawa Y, Yukawa O, Ohnishi T.: The dependence of p53 on the radiation enhancement of thermosensitivity at different LET. Int J Radiat Oncol Biol Phys. 47: 489-494, 2000.


37.Ota I, Ohnishi K, Takahashi A, Yane K, Kanata H, Miyahara H, Ohnishi T, Hosoi H.: Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 47: 495-501, 2000.


38.Ohnishi T, Komatsu K, Tauchi H, Wang X, Takahashi A, Ohnishi K, Shiba A, Matsumoto H.: Heat-induced accumulation of p53 and hsp72 is suppressed in lung fibroblasts from Scid mouse. Int J Radiat Biol. 76: 711-715, 2000.


39.Takahashi A, Ohnishi K, Takahashi S, Masukawa M, Sekikawa K, Amano T, Nakano T, Nagaoka S, Ohnishi T.: The effects of microgravity on ligase activity in the repair of DNA double-strand breaks. Int J Radiat Biol. 76: 783-788, 2000.


40.Ohnishi T, Takahashi A, Ohnishi K, Nakano T. Nagaoka S.: Enzymic chemical reaction under microgravity environment in space. J Gravit Phys. 7: 69-70, 2000.


41.Yatagai F, Saito T, Takahashi A, Fujie A, Nagaoka S, Sato M, Ohnishi T.: rpsL mutation induction after space flight on MIR. Mutat Res (Fund Mol Mech Mutag). 453: 1-4, 2000.


42.Kanata H, Yane K, Ota I, Miyahara H, Matsunaga T, Takahashi A, Ohnishi K, Ohnishi T, Hosoi H.: CDDP induces p53-dependent apoptosis in tongue cancer cells. Int J Oncol. 17: 513-518, 2000.


43.Fukuda T, Fukuda K, Takahashi A, Ohnishi T, Nakano T, Sato M, Gunge N.: Analysis of deletion mutation of the rpsL gene in yeast Saccharomyces cerevisiae detected after long-term flight on the Russian space station Mir. Mutat Res (Gen Tox En Mutag). 470: 125-132, 2000.


44.Ohnishi K, Ota I, Takahashi A, Ohnishi T.: Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53. Br J Cancer. 83: 1735-1739, 2000.


45.Takahashi A.: Different inducibility of radiation- or heat-induced p53-dependent apoptosis after acute or chronic irradiation in human cultured squamous cell carcinoma cells. Int J Radiat Biol. 77: 215-224, 2001.


46.Takahashi A, Ohnishi K, Asakawa I, Kondo N, Nakagawa H, Yonezawa M, Tachibana A, Matsumoto H, Ohnishi T.: Radiation response of apoptosis in C57BL/6N mouse spleen after whole-body irradiation. Int J Radiat Biol. 77: 939-946, 2001.


47.Takahashi A, Ohnishi K, Ota I, Asakawa I, Tamamoto T, Furusawa Y, Matsumoto H, Ohnishi T.: p53-dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET. Int J Radiat Biol. 77: 1043-1051, 2001.


48.Ohnishi T, Takahashi A, Ohnishi K, Takahashi S, Masukawa M, Sekikawa K, Amano T, Nakano T, Nagaoka S.: Alkylating agent (MNU)-induced mutation in space environment. Adv Space Res. 28: 563-568, 2001.


49.Takahashi A, Ohnishi K, Takahashi S, Masukawa M, Sekikawa K, Amano T, Nakano T, Nagaoka S, Ohnishi T.: The effects of microgravity on induced-mutation in Escherichia coli and Saccharomyces cerevisiae. Adv Space Res. 28: 555-561, 2001.


50.Takahashi A, Ohnishi K, Takahashi S, Masukawa M, Sekikawa K, Amano T, Nakano T, Nagaoka S, Ohnishi T.: Differentiation of Dictyostelium discoideum vegetative cells into spores during Earth orbit in space. Adv Space Res. 28: 549-553, 2001.


51.Masunaga S, Ono K, Takahashi A, Ohnishi T, Kinashi Y, Takagaki M.: Radiobiological characteristics of solid tumours depending on the p53 status of the tumour cells, with emphasis on the response of intratumour quiescent cells. Eur J Cancer. 18: 718-727, 2002.


52.Ohnishi K, Ota I, Takahashi A, Yane K, Ohnishi T.: Transfection of mutant p53 gene depresses X-ray- or CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neck. Apoptosis. 7: 367-372, 2002.


53.Ohnishi K, Yamamoto T, Ogawa Y, Takahashi A, Yamashita M, Ohnishi T.: High transmittance of X-rays in the utricular otolith of upside-down swimming catfish, Synodontis nigriventris. Biol Sci Space. 16: 18-21, 2002.


54.Ohnishi T, Ohnishi K, Takahashi A.: Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53. BMC Biotechnol. 2: 6, 2002.


55.Asakawa I, Yoshimura H, Takahashi A, Ohnishi K, Nakagawa H, Ota I, Furusawa Y, Tamamoto T, Ohishi H, Ohnishi T.: Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status. Anticancer Res. 22: 2037-2043, 2002.


56.Takahashi A, Asakawa I, Yuki K, Matsumoto T, Kumamoto M, Kondo N, Ohnishi K, Tachibana A, Ohnishi T.: Radiation-induced apoptosis in scid mouse spleen after low dose-rate irradiation. Int J Radiat Biol. 78: 689-693, 2002.


57.Masunaga S, Ono K, Takahashi A, Sakurai Y, Ohnishi K, Kobayashi T, Kinashi Y, Takagaki M, Ohnishi T.: Impact of p53 status of the tumor cells on the effect of reactor neutron beam irradiation, with emphasis on the response of intratumor quiescent cells. Jpn J Cancer Res (Cancer Sci). 93: 1366-1377, 2002.


58.Ohnishi K, Ota I, Yane K, Takahashi A, Yuki K, Emoto M, Hosoi H, Ohnishi T.: Glycerol as a chemical chaperone enhanced radiation-induced apoptosis in anaplastic thyroid carcinoma cells. Mol Cancer. 1: 4, 2002.


59.Masunaga S, Ono K, Takahashi A, Ohnishi K, Ohnishi T, Suzuki M, Nagata K, Kinashi Y, Nagasawa H, Uto Y, Hori H.: Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status. Cancer Sci. 94: 125-133, 2003.


60.Yasumoto J, Imai Y, Takahashi A, Ohnishi K, Yuki K, Kirita T, Ohnishi T.: Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene. J Radiat Res (Tokyo). 44: 41-45, 2003.


61.Takahashi A, Ota I, Tamamoto T, Asakawa I, Nagata Y, Nakagawa H, Kondo N, Ohnishi K, Furusawa Y, Matsumoto H, Ohnishi T.: p53-dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation. Int J Hyperthermia. 19: 145-153, 2003.


62.Masunaga S, Takahashi A, Ohnishi K, Ohnishi T, Suzuki M, Nagata K, Kinashi Y, Ono K.: Effects of p53 status and wortmannin treatment on potentially lethal damage repair, with emphasis on the response of intratumor quiescent cells. Radiat Med. 21: 120-127, 2003.


63.Tamamoto T, Yoshimura H, Takahashi A, Asakawa I, Ota I, Nakagawa H, Ohnishi K, Ohishi H, Ohnishi T.: Heat-induced growth inhibition and apoptosis in transplanted human head and neck squamous cell carcinomas with different status of p53. Int J Hyperthermia. 19: 590-597, 2003.


64.Takahashi A, Kondo N, Inaba H, Uotani K, Kiyohara Y, Ohnishi K, Ohnishi T.: Radiation-induced apoptosis in scid mice spleen after low dose irradiation. Adv Space Res. 31: 1569-1573, 2003.


65.Yasumoto J, Kirita T, Takahashi A, Ohnishi K, Imai Y, Yuki K, Ohnishi T.: Apoptosis-related gene expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53. Cancer Lett. 204: 41-51, 2004.


66.Yuki K, Takahashi A, Ota I, Ohnishi K, Yasumoto J, Kanata H, Yane K, Hosoi H, Ohnishi T.: Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 gene. Oncol Rep. 11: 821-824, 2004.


67.Ohnishi K, Takahashi A, Yokota S, Ohnishi T.: Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status. Int J Radiat Biol. 80: 607-614, 2004.


68.Ohnishi K, Inaba H, Yasumoto J, Yuki K, Takahashi A, Ohnishi T.: C-terminal peptides of p53 molecules enhance radiation-induced apoptosis in human mutant p53 cancer cells. Apoptosis. 9: 591-597, 2004.


69.Masunaga S, Takahashi A, Ohnishi K, Ohnishi T, Nagata K, Suzuki M, Kinashi Y, Ono K.: Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations. Int J Radiat Oncol Biol Phys. 60: 570-577, 2004.


70.Yuki K, Takahashi A, Ota I, Ohnishi K, Yasumoto J, Yane K, Kanata H, Okamoto N, Hosoi H, Ohnishi T.: Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene. Apoptosis. 9: 853-859, 2004.


71.Takahashi A, Matsumoto H, Yuki K, Yasumoto J, Kajiwara A, Aoki M, Furusawa Y, Ohnishi K, Ohnishi T.: High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status. Int J Radiat Oncol Biol Phys. 60: 591-597, 2004.


72.Takahashi A, Matsumoto H, Nagayama K, Kitano M, Hirose S, Tanaka H, Mori E, Yamakawa N, Yasumoto J, Yuki K, Ohnishi K, Ohnishi T.: Evidence for the involvement of double-strand breaks in heat-induced cell killing. Cancer Res. 64: 8839-8845, 2004.


73.Takahashi A, Ohnishi K, Ohnishi T.: Radiation-induced apoptosis in SCID mouse spleen after low dose or low dose-rate irradiation. Int J Low Radiat. 1: 199-207, 2004.


74.Ohnishi K, Ogawa Y, Takahashi A, Yamashita M, Ohnishi T.: Comparative study of otolith organs between two species of upside-down swimming catfish Synodontis nigriventris showing converse swimming postures. Acta Zool. 85: 201-209, 2004.


75.Imai Y, Ohnishi K, Yasumoto J, Kajiwara A, Yamakawa N, Takahashi A, Ohnishi T, Kirita T.: Glycerol enhances radiosensitivity in a human oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 gene via Bax-mediated induction of apoptosis. Oral Oncol. 41: 631-636, 2005.


76.Takahashi A, Kumatani T, Usui S, Tsujimura R, Seki T, Morimoto K, Ohnishi T.: Photoreactivation in Paramecium tetraurelia under conditions of various degrees of ozone layer depletion. Photochem Photobiol. 81: 1010-1014, 2005.


77.Masunaga S, Nagasawa H, Uto Y, Hori H, Ohnishi K, Takahashi A, Ohnishi T, Suzuki M, Nagata K, Kinashi Y, Ono K.: Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells. Oncol Rep. 14: 393-400, 2005.


78.Takahashi A, Matsumoto H, Furusawa Y, Ohnishi K, Ishioka N, Ohnishi T.: Apoptosis induced by high-LET radiations is not affected by cellular p53 gene status. Int J Radiat Biol. 81: 581-586, 2005.


79.Takahashi A, Shibata N, Nishikawa S, Ohnishi K, Ishioka N, Ohnishi T.: UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilis. Photochem Photobiol Sci. 5: 467-471, 2006.


80.Ohnishi K, Yasumoto J, Takahashi A, Ohnishi T.: LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells. Int J Oncol. 29: 249-253, 2006.


81.Ohnishi K, Yokota S, Takahashi A, Ohnishi T.: Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells. Int J Radiat Biol. 82: 569-575, 2006.


82.Ohnishi K, Scuric Z, Schiestl RH, Okamoto N, Takahashi A, Ohnishi T.: siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status. Radiat Res. 166: 454-462, 2006.


83.Ohnishi K, Scuric Z, Yau D, Schiestl RH, Okamoto N, Takahashi A, Ohnishi T.: Heat-induced phosphorylation of NBS1 in human skin fibroblast cells. J Cell Biochem. 99: 1642-1650, 2006.


84.Matsumoto H, Takahashi A, Ohnishi T.: Nitric oxide radicals choreograph a radioadaptive response. Cancer Res. 67: 8574-8579, 2007.


85.Masunaga S, Takahashi A, Ohnishi K, Nagata K, Suzuki M, Kashino G, Kinashi Y, Ohnishi T, Ono K.: Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population. Oncol Rep. 18: 1589-1596, 2007.


86.Mori E, Takahashi A, Kitagawa K, Kakei S, Tsujinaka D, Unno M, Nishikawa S, Ohnishi K, Hatoko M, Murata N, Watanabe M, Furusawa Y, Ohnishi T.: Time course and spacial distribution of UV effects on human skin in organ culture. J Radiat Res (Tokyo). 49: 269-277, 2008.


87.Takahashi A, Yamakawa N, Mori E, Ohnishi K, Yokota S, Sugo N, Aratani Y, Koyama H, Ohnishi T.: Development of thermotolerance requires interaction between polymerase β and heat shock proteins. Cancer Sci. 99: 973-978, 2008.


88.Takahashi A, Matsumoto H, Ohnishi T.: Hdm2 and nitric oxide radicals contribute to the p53-dependent radioadaptive response. Int J Radiat Oncol Biol Phys. 71: 550-558, 2008.


89.Ohnishi K, Nagata Y, Takahashi A, Taniguchi S, Ohnishi T.: Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP. Oncol Rep. 20: 57-61, 2008.


90.Yamakawa N, Takahashi A, Mori E, Imai Y, Furusawa Y, Ohnishi K, Kirita T, Ohnishi T.: High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation. Cancer Sci. 99: 1455-1460, 2008.


91.Takahashi A, Mori E, Somakos GI, Ohnishi K, Ohnishi T.: Heat induces γH2AX foci formation in mammalian cells. Mutat Res (Gen Tox En Mutag). 656: 88-92, 2008.


92.Takahashi A, Yamakawa N, Kirita T, Omori K, Ishioka N, Furusawa Y, Mori E, Ohnishi K, Ohnishi T.: DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus. J Radiat Res (Tokyo). 49: 645-652, 2008.


93.Kajihara A, Takahashi A, Ohnishi K, Imai Y, Yamakawa N, Yasumoto J, Ohnishi T, Kirita T.: Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes. Int J Hyperthermia. 24: 605-612, 2008.


94.Somakos GI, Takahashi A, Mori E, Ohnishi T.: Computational image processing and analysis of heat-induced γH2AX foci. Thermal Med. 25: 25-34, 2009.


95.Takahashi A, Ohnishi T.: A priming heat treatment can induce the development of heat- and radio-resistance via HSPs, regardless of p53-gene status. Thermal Med. 25: 13-23, 2009.


96.Ohnishi T, Takahashi A, Suzuki H, Omori K, Shimazu T, Ishioka N.: Expression of p53-regulated genes in cultured mammalian cells after exposure to a space environment. Biol Sci Space. 23: 3-10, 2009.


97.Yatagai F, Takahashi A, Honma M, Suzuki H, Omori K, Seki M, Hashizume T, Shimazu T, Enomoto S, Ohnishi T, Ishioka N.: LOH analyses for biological effects of space radiation: human cell culture in “Kibo” of International Space Station. Biol Sci Space. 23: 11-16, 2009.


98.Yamagata R, Takahashi A, Su X, Morimoto T, Ohnishi T.: Restraint plus water-immersion stress (RWIS)-induced stomach ulcers in mice are depressed by a conditioning heat treatment. Thermal Med. 25: 81-87, 2009.


99.Kondo N, Takahashi A, Mori, E, Ohnishi K, McKinnon PJ, Sakaki T, Nakase H, Ohnishi T.: DNA ligase IV as a new molecular target for temozolomide. Biochem Biophys Res Commun. 387: 656-660, 2009.


100.Ohnishi T, Takahashi A, Nagamatsu A, Omori K, Suzuki H, Shimazu T, Ishioka N.: Detection of space radiation-induced double strand breaks as a track in cell nucleus. Biochem Biophys Res Commun. 390: 485-488, 2009.


101.Toki A, Takahashi A, Tachibana S.: Chemotherapy combined with hyperthermia improves the prognosis for non-small-cell lung cancer. Thermal Med. 25: 115-122, 2009.


102.Takahashi A, Ohnishi T.: A low dose pre-irradiation induces radio- and heat-resistance via HDM2 and NO radicals, and is associated with p53 functioning. Adv Space Res. 43: 1185-1192, 2009.


103.Masunaga S, Tano K, Nakamura J, Watanabe M, Kashino G, Takahashi A, Tanaka H, Suzuki M, Ohnishi K, Kinashi Y, Liu Y, Ohnishi T, Ono K.: Usefulness of hexamethylenetetramine as an adjuvant to radiation and cisplatin in the treatment of solid tumors: its independency of p53 status. J Radiat Res (Tokyo). 51: 27-35, 2010.


104.Takahashi A, Mori E, Ohnishi T.: The foci of DNA double strand break-recognition proteins localize with γH2AX after heat treatment. J Radiat Res (Tokyo). 51: 91-95, 2010.


105.Su X, Takahashi A, Guo G, Mori E, Okamoto N, Ohnishi K, Iwasaki T, Ohnishi T.: Biphasic effects of nitric oxide radicals on radiation-induced lethality and chromosome aberrations in human lung cancer cells carrying different p53 gene status. Int J Radiat Oncol Biol Phys. 77: 559-565, 2010.


106.Takahashi A, Mori E, Su X, Nakagawa Y, Okamoto N, Uemura H, Kondo N, Noda T, Toki A, Ejima Y, Chen JD, Ohnishi K, Ohnishi T.: ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating. J Radiat Res (Tokyo). 51: 417-422, 2010.


107.Takahashi A, Suzuki H, Omori K, Seki M, Hashizume T, Shimazu T, Ishioka N, Ohnishi T.: The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight. Int J Radiat Biol. 86: 669-681, 2010.


108.Kondo N, Takahashi A, Mori E, Noda T, Su X, Ohnishi K, McKinnon P, Sakaki T, Nakase H, Ono K, Ohnishi T.: DNA ligase IV is a potential molecular target in ACNU sensitivity. Cancer Sci. 101: 1881-1885, 2010.


109.Nagata Y, Takahashi A, Ohnishi K, Ota I, Ohnishi T, Tojo T, Taniguchi S.: Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status. Int J Oncol. 37: 1001-1010, 2010.


110.Takahashi A, Su X, Suzuki H, Omori K, Seki M, Hashizume T, Shimazu T, Ishioka N, Iwasaki T, Ohnishi T.: p53-Dependent adaptive responses in human cells exposed to space radiations. Int J Radiat Oncol Biol Phys. 78: 1171-1176, 2010.


111.Takahashi A, Suzuki H, Omori K, Seki M, Hashizume T, Shimazu T, Ishioka N, Ohnishi T.: Expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines after spaceflight in a frozen state. Adv Space Res. 47: 1062-1070, 2011.


112.Noda T, Takahashi A, Kondo N, Moria E, Okamoto N, Nakagawa Y, Ohnishi K, Zdzienicka MZ, Thompson LH, Helleday T, Asada H, Ohnishi T.: Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage. Biochem Biophys Res Commun. 404: 206-210, 2011.


113.Yatagai F, Honma M, Takahashi A, Omori K, Suzuki H, Shimazu T, Seki M, Hashizume T, Ukai A,  Sugasawa K, Abe T, Dohmae N, Enomoto S, Ohnishi T, Gordon A, Ishioka N.: Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptation. Radiat Environ Biophys. 50: 125-134, 2011.


114.Okamoto N, Takahashi A, Ota I, Ohnishi K, Mori E, Kondo N, Noda T, Nakagawa Y, Uemura H, Yane K, Hosoi H, Ohnishi T.: siRNA targeted for nbs1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells. Int J Hyperthermia. 27: 297-304, 2011.


115.Kondo N, Takahashi A, Mori E, Ohnishi K, Zdzienicka ZM, Thompson HL, Nakase H, Sakaki T, Ono K, Ohnishi T.: FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS ONE. 6: e19659, 2011.


116.Su X, Takahashi A, Kondo N, Nakagawa Y, Iwasaki T, Guo G, Ohnishi T.: Nitric oxide radical-induced radioadaptation and radiosensitization are G2/M phase-dependent. J Radiat Res (Tokyo)52: 609-615, 2011.


117.Furusawa Y, Fujiwara Y, Campbell P, Zhao Q-L, Ogawa R, Hassan MA, Tabuchi Y, Takasaki I, Takahashi A, Kondo T.: DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines. PLoS ONE. 7: e29012, 2012.


118.Yatagai F, Honma M, Ukai A, Omori K, Suzuki H, Shimazu T, Takahashi A, Ohnishi T, Dohmae N, Ishioka N.: Preliminary results of space experiment: implications for the effects of space radiation and microgravity on survival and mutation induction in human cells. Adv Space Res. 49: 479-486, 2012.


119.Takahashi A, Suzuki H, Omori K, Seki M, Hashizume T, Shimazu T, Ishioka N, Ohnishi T.: Expression of p53-regulated proteines in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight. J Radiat Res (Tokyo). 53: 168-175, 2012.


120.Miura K, Sakata KI, Someya M, Matsumoto Y, Matsumoto H, Takahashi A, Hareyama M.: The combination of olaparib and camptothecin for effective radiosensitization. Radiat Oncol7: 62, 2012.


121.Nakagawa Y, Takahashi A, Kajihara A, Yamakawa N, Imai Y, Ota I, Okamoto N, Mori E, Noda T, Furusawa Y, Kirita T, Ohnishi T.: Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation. Biochem Biophys Res Commun. 423: 654-660, 2012.


122.Shimura T, Noma N, Oikawa T, Ochiai Y, Kakuda S, Kuwahara Y, Takai Y, Takahashi A, Fukumoto M.: Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells. Oncogenesis. 1: e12, 2012.


123.Watanabe K, Miyagawa R, Tomikawa C, Mizuno R, Takahashi A, Hori H, Ijiri K.: Degradation of initiator tRNAMet by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells. Nucleic Acids Res. 41: 4671-4685, 2013.


124.Nakagawa Y, Kajihara A, Takahashi A, Kondo N, Mori E, Kirita T, Ohnishi T.: The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells. Oncol Rep. 31: 2001-2006, 2014.


125.Murata K, Noda S, Oike T, Takahashi A, Yoshida Y, Suzuki Y, Ohno T, Funayama T, Kobayashi Y, Takahashi T, Nakano T.: Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells. J Radiat Res. 55: 658-664, 2014.


126.Takahashi A, Kubo M, Ma H, Nakagawa A, Yoshida Y, Isono M, Kanai T, Ohno T, Furusawa Y, Funayama T, Kobayashi Y, Nakano T.: NHEJ repair plays a more important role than HR repair in defining radiosensitivity after exposure to high LET radiation. Radiat Res. 182: 338-344, 2014.



127.Takahashi A, Ma H, Nakagawa A, Yoshida Y, Kanai T, Ohno T, Kuwahara Y, Fukumoto M, Nakano T.: Carbon-ion beams efficiently induce cell killing in X-ray resistant human squamous tongue cancer cells. Int J Med Phys Clin Engin Radiat Oncol. 3: 133-142, 2014.


128. Kubo N, Noda S, Takahashi A, Yoshida Y, Oike T, Murata K, Musha A, Suzuki Y, Ohno T, Takahashi T, Nakano T.: Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small cell lung cancer cell line H460. J Radiat Res. 2014, in press

業 績

原著論文

髙 橋 昭 久

准教授

先端医学・生命科学研究チーム

放射線生物学分野