Japanesepublications-dkohno.html
 

Original Papers

(1) Kim KW, Donato J Jr, Berglund ED, Choi YH, Kohno D, Elias CF, DePinho RA, Elmquist JK:  FoxO1 Regulates Energy Balance and Glucose Homeostasis in Neurons in the Ventral Medial Nucleus of the Hypothalamus. J Clin Invest 122: 2578-2589, 2012


(2) Maejima Y, Kohno D, Iwasaki Y, Yada T: Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus. Aging (Albany NY) 3:1092-1097, 2011


(3) Chuang JC, Sakata I, Kohno D, Perello M, Osborne-Lawrence S, Repa JJ, Zigman JM: Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic -Cells. Mol Endocrinol. 25:1600-1611, 2011


(4) Kohno D, Sone H, Tanaka S, Kurita H, Gantulga D, Yada T: AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. Neurosci Lett. 499, 194-198, 2011


(5) Kim KW, Zhao L, Donato J Jr, Kohno D, Xu Y, Elias CF, Lee C, Parker KL, Elmquist JK: Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A 108, 10673-10678, 2011


(6) Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, Oh-I S, Hashimoto K, Shimizu H, Nakata M, Mori M, Yada T: Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab 10, pp355-365, 2009


(7) Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK: 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 60, 582-589, 2008


(8) Kohno D, Suyama S, Yada T: Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca2+ signaling in neuropeptide Y neurons of the arcuate nucleus. World J Gastroenterol 14, 6347-6354, 2008


(9) Kohno D, Sone H, Minokoshi Y, Yada T:Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons. Biochem Biophys Res Commun 366, 388-392, 2008


(10)Kohno D, Nakata M, Maejima Y, Shimizu H, Sedbazar U, Yoshida N, Dezaki K, Onaka T, Mori M, Yada T: Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology 149, 1295-1301, 2008


(11)Hori Y, Kageyama H, Guan JL, Kohno D, Yada T, Takenoya F, Nonaka N, Kangawa K, Shioda S, Yoshida T: Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus. Regul Pept 145, 122-127, 2008


(12)Kohno D, Nakata M, Maekawa F, Fujiwara K, Maejima Y, Kuramochi M, Shimazaki T, Okano H, OnakaT, Yada T:Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway. Endocrinology 148, 2251-2263, 2007


(13)Maekawa F, Fujiwara K, Kohno D, Kuramochi M, Kurita H, Yada T: Young adult-specific hyperphagiain diabetic Goto-Kakizaki rats is associated with leptin resistance and elevation of neuropeptide Y mRNA in the arcuate nucleus. J Neuroendocrinology 18, 748-756, 2006


(14)Oomura Y, Hori N, Shiraishi T, Fukunaga K, Takeda H, Tsuji M, Matsumiya T, Ishibashi M, Aou S, Li XL, Kohno D, Uramura K, Sougawa H, Yada T, Wayner MJ, Sasaki K. Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides 27, 2738-2749, 2006


(15)Kuramochi M, Onaka T, Kohno D, Kato S, Yada T: Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rats. Endocrinology 147, 1744-1752, 2006


(16)Kuramochi M, Kohno D, Onaka T, Kato S, Yada T: Galanin-like peptide and ghrelin increase cytosolic Ca2+ in neurons containing growth hormone-releasing hormone in the arcuate nucleus. Regulatory Peptide 126, 85-89, 2005


(17)Nakata M, Kohno D, Shintani N, Nemoto Y, Hashimoto H, Baba A, Yada T: PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus. Neurosci Lett 370, 252-256, 2004


(18)Muroya S, Funahashi H, Yamanaka A, Nambu T, Shibahara M, Uramura K, Kohno D, Kuramochi M, Onaka T, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T: Orexins (Hypocretins) Directly Interacts with Neuropeptide Y, POMC and Glucose-Responsive Neurons to Regulate Ca2+ Signaling in a Reciprocal Manner to Leptin: Orexigenic Neuronal Pathways in the Mediobasal Hypothalamus. Eur J Neurosci 19, 1524-1534, 2004


(19)Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T: Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus: Ca2+ Signaling via Protein Kinase A and N-Type Channel-Dependent Mechanisms and Cross-Talk With Leptin and Orexin. Diabetes 52, 948-956, 2003


(20)Zhou CJ, Yada T, Kohno D, Kikuyama S, Suzuki R, Mizushima H, Shioda S: PACAP activates PKA, PKC and Ca2+ signaling cascades in rat neuroepithelial cells. Peptides 22, 1111-1117, 2001

Daisuke Kohno

Assistant Professor

Lifestyle-related disease Field

Advanced Medicine / Bioscience Research Team