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業 績

原著論文

平川 秀忠

助教

先端医学・生命科学研究チーム

医学・生命科学分野

1. Kurabayashi K, Hirakawa Y, Tanimoto K, Tomita H, Hirakawa H.*: The role of the CpxAR two-component signal transduction system in control of fosfomycin resistance and carbon substrate uptake. Journal of Bacteriology. in press (*Corresponding author)


2. Hirakawa H*, and Tomita H.: Interference of bacterial cell-to-cell communication: a new concept of antimicrobial chemotherapy breaks antibiotic resistance. Frontiers in Microbiology. 4:114, 2013 (*Corresponding author)


3. Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP.: Antisense RNA that

affects Rhodopseudomonas palustris quorum-sensing signal receptor expression. Proceedings of National Academy of Sciences of the United States of America. 109: 12141-12146, 2012


4. Phattarasukol S, Radey MC, Lappala CR, Oda Y, Hirakawa H, Brittnacher MJ, Harwood CS.: Identification of a p-coumarate degradation regulon in Rhodopseudomonas palustris using Xpression, an integrated tool for prokaryotic RNA-seq data processing. Applied and Environmental Microbiology. 78: 6812-6818, 2012


5. Hirakawa H, Schaefer AL, Greenberg EP, Harwood CS.: Anaerobic p-coumarate degradation by Rhodopseudomonas palustris and identification of CouR, a MarR repressor protein that binds p-coumaroyl Coenzyme A. Journal of Bacteriology. 194: 1960-1967, 2012


6. Hirakawa H, Oda Y, Phattarasukol S, Armour CD, Castle JC, Raymond CK, Lappala CR, Schaefer AL, Harwood CS, Greenberg EP.: Activity of the Rhodopseudomonas palustris p-coumaroyl-homoserine lactone-responsive transcription factor RpaR. Journal of Bacteriology. 193: 2598-2607, 2011


7. Hirakawa H, Hayashi-Nishino M, Yamaguchi A, Nishino K.: Indole enhances acid resistance in Escherichia coli. Microbial Pathogenesis. 49: 90-94, 2010


8. Yamada J, Yamasaki S, Hirakawa H, Hayashi-Nishino M, Yamaguchi A, Nishino K.: Impact of the RNA chaperone Hfq on multidrug resistance in Escherichia coli. Journal of Antimicrobial Chemotherapy. 65: 853-858, 2010


9. Hirakawa H, Kodama T, Takumi-Kobayashi A, Honda T, Yamaguchi A.: Secreted indole serves as a signal for expression of type III secretion system translocators in enterohaemorrhagic Escherichia coli O157 :H7. Microbiology. 155: 541-550, 2009


10. Hirakawa H, Takumi-Kobayashi A, Theisen U, Hirata T, Yamaguchi A.: AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli. Journal of Bacteriology. 190: 6276-6279, 2008


11. Hirakawa H, Inazumi Y, Senda Y, Kobayashi A, Hirata T, Nishino K, Yamaguchi A.: N-acetyl-D-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite control activation in Escherichia coli. Journal of Bacteriology. 188: 5851-5858, 2006


12. Kobayashi A, Hirakawa H, Hirata T, Nishino K, Yamaguchi A.: Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance. Journal of Bacteriology. 188: 5693-5703, 2006


13. Hirakawa H, Inazumi Y, Masaki T, Hirata T, Yamaguchi A.: Indole induces the expression of multidrug exporter genes in Escherichia coli. Molecular Microbiology. 55: 1113-1126, 2005


14. Shimoda K, Kubota N, Sano T, Hirakawa H, Hirata T.: A novel hydroxylase from Catharanthus roseus participating in the hydroxylation of 2-hydroxybenzoic acid. Journal of Bioscience and Bioengineering. 98: 67-70, 2004


15. Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.: β-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Journal of Antimicrobial Chemotherapy. 52: 576-582, 2003


16. Hirakawa H, Nishino K, Hirata T, Yamaguchi A.: Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Journal of Bacteriology. 185: 1851-1856, 2003


17. Nishino K, Yamada J, Hirakawa H, Hirata T, Yamaguchi A.: Roles of TolC-dependent type multidrug transporters of Escherichia coli in resistance to β-lactam antibiotics. Antimicrobial Agents and Chemotherapy. 47: 3030-3033, 2003


18. Shimoda K, Yamane S, Hirakawa H, Ohta S, Hirata T.: Biotransformation of phenolic compounds by the cultured cells of Catharanthus roseus. Journal of Molecular Catalysis B: Enzymatic. 16: 275-281, 2002