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業 績

原著論文

原著

1.  Yamamoto, M., Meno, C., Sakai, Y., Shiratori, H., Mochida, K., Ikawa, Y., Saijoh, Y., and Hamada, H.*

A transcription factor FoxH1/FAST mediates Nodal signaling during anterio-posterior patterning and node formation in the mouse.

    Genes & Development. 12: 1242-1256. 2001.


2.  Yamamoto, M., Mine, N., Mochida, K., Sakai, Y., Saijoh, Y., Meno, C., and Hamada, H. *

    Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate.

    Development. 130: 1795-1804. 2003.


3.  Yamamoto, M., Saijoh, Y., Perea-Gomez, A., Shawlot, W., Behringer, R., Ang, S.-L.,

    Hamada, H. * and Meno, C.

    Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo.

    Nature (Article). 428: 387-392. 2004.


4.Kobayashi, S., Isotani, A., Mise, N., Yamamoto, M., Fujihara, Y., Kaseda, K., Nakanishi, T.,  Ikawa, M., Hamada, H., Abe, K. and Okabe, M. *

    Comparison of gene expression between male and female mouse blastocysts revealed

    imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages.

    Current Biology. 16: 1-7. 2006.


5.  Takaoka, K., Yamamoto, M., Shiratori, H., Meno, C., Rossant, J., Saijoh, Y.and Hamada, H. *

    The mouse embryo autonomously acquires anterior-posterior polarity at implantation.

    Developmental Cell. 10: 451-459. 2006.


6.  Nakamura, T., Mine, N., Nakaguchi, N. *, Mochizuki, A., Yamamoto, M., Yashiro, K.,

  Meno, C. and Hamada, H. *

    Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a

    Self-Enhancement and Lateral-Inhibition System.

    Developmental Cell. 11: 495-504. 2006


7.  Takeuchi, J. K., Lickert, H., Bisgrove, B. W., Sun, X., Yamamoto, M., Chawengsaksophak, K.,

    Hamada, H., Yost, H. J., Rossant, J. and Bruneau, B. G. *

    Baf60c is a nuclear Notch signaling component required for the establishment of left–right

    asymmetry.

    Proceedings of the National Academy of Sciences of the United States of America.

    104: 846-851. 2007.


8.  Yamamoto, M. *, Beppu, H., Takaoka, K., Meno, C., Li, E., Miyazono, K. and Hamada, H. *

    Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral

    endoderm formation in the mouse embryo.

    The Journal of Cell Biology. 184: 323-334. 2009.


9.  Uehara, M., Yashiro, K., Takaoka, K., Yamamoto, M. and Hamada, H. *

    Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal

    expression during early embryonic patterning.

    Genes & Development. 23: 1689-98. 2009.


10. Takaoka, K., Yamamoto, M. and Hamada, H. (2011)

     Origin and role of distal visceral endoderm, a group of cells that determines anterior-posterior polarity

     of  the mouse embryo.            

     Nature Cell Biology (Article) 13:743-52


11. Aoyama, M., Sun-Wada, G., Yamamoto, A., Yamamoto, M., Hamada, H. and Wada Y. (2012)

     Spatial restriction of bone morphogenetic protein signaling in mouse gastrula thorough the mVam2-

     dependent endocytic pathway.

     Developmental Cell 22: 1163-1175.



総説

1.  山本正道

    マウスにおける体の非対称性、頭尾軸形成機構について

  THE LUNG perspectives. 12: 308-317. 2004.


2.  Takaoka, K., Yamamoto, M., and Hamada, H. 

     Origin of body axes in the mouse embryo.

     Current Opinion in genetics & development. 17: 344-50. 2007.

山本 正道

助教

先端医学・生命科学研究チーム

医学・生命科学分野