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原著論文

Hiroshi Kadokura*, Michiko Saito, Akio Tsuru, Akira Hosoda, Takao Iwawaki, Kenji Inaba, Kenji Kohno* "Identification of the redox partners of ERdj5 /JPDI, a PDI family member, from an animal tissue" Biochem. Biophys. Res. Commun., vol. 440, 245-250, 2013.


Timon E. Adolph, Michal F. Tomczak, Lukas Niederreiter, Hyun-Jeong Ko, Janne Böck, Eduardo Martinez-Naves, Jonathan N. Glickman, Markus Tschurtschenthaler, John Hartwig, Shuhei Hosomi, Magdalena B. Flak, Jennifer L. Cusick, Kenji Kohno, Takao Iwawaki, Susanne Billmann-Born, Richta Bharti, Ralph Lucius, Mi-Na Kweon, Stefan J. Marciniak, Augustine Choi, Susan J. Hagen, Stefan Schreiber, Philip Rosenstie, Arthur Kaser*, Richard S. Blumberg* "Paneth cells as a site of origin for intestinal inflammation" Nature, vol. 503, 272-276, 2013.


Manabu Taura, Ryusho Kariya, Eriko Kudo, Hiroki Goto, Takao Iwawaki, Masayuki Amano, Mary Ann Suico, Hirofumi Kai, Hiroaki Mitsuya, Seiji Okada* "Comparative analysis of ER stress response into HIV protease inhibitors: Lopinavir but not Darunavir induces potent ER stress response via ROS/JNK pathway" Free Radic. Biol. Med., vol. 65, 778-788, 2013.


Lukas Niederreiter, Teresa M. J. Fritz, Timon E. Adolph, Anna-Maria Krismer, Felix A. Offner, Markus Tschurtschenthaler, Magdalena B. Flak, Shuhei Hosomi, Michal F. Tomczak, Nicole C. Kaneider, Edina Sarcevic, Sarah Kempster, Tim Raine, Philip Rosenstiel, Kenji Kohno, Takao Iwawaki, Herbert Tilg, Richard S. Blumberg*, Arthur Kaser* "ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells" J. Exp. Med., vol. 210, 2041-2056, 2013.


Yuto Kitai, Hiroyuki Ariyama, Nozomu Kono, Daisuke Oikawa, Takao Iwawaki, Hiroyuki Arai* "Membrane lipidsaturation activates IRE1α without clustering" Genes Cells, vol. 18, 798-809, 2013.


Dotan Uzi, Liran Barda, Viviana Scaiewicz, Maya Mills, Tobias Mueller, Agueda Gonzalez-Rodriguez, Angela M. Valverde, Takao Iwawaki, Yaakov Nahmias, Ramnik J. Xavier, Raymond T. Chung, Boaz Tirosh*, Oren Shibolet* "CHOP is a critical regulator of acetaminophen-induced hepatotoxicity" J. Hepatol., vol. 59, 495-503, 2013.

 

Daisuke Oikawa, Takao Iwawaki* "Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins" Biochem. Biophys. Res. Commun., vol. 433, 426-431, 2013.

 

Joby Josekutty, Jahangir Iqbal, Takao Iwawaki, Kenji Kohno, M. Mahmood Hussain* "MTP inhibition induces ER stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST" J. Biol. Chem., vol. 288, 14372-14383, 2013.

 

Akio Tsuru, Naoko Fujimoto, Satsuki Takahashi, Michiko Saito, Daisuke Nakamura, Megumi Iwano, Takao Iwawaki, Hiroshi Kadokura, David Ron, Kenji Kohno* "Negative feedback by IRE1β optimizes mucin production in goblet cells" Proc. Natl. Acad. Sci. USA, vol. 110, 2864-2869, 2013.

 

Chih-Kang Chiang, Masaomi Nangaku, Tetsuhiro Tanaka, Takao Iwawaki, Reiko Inagi* "Endoplasmic reticulum (ER) stress signal impairs erythropoietin production: a role for ATF4" Am. J. Physiol. Cell Physiol., vol. 304, C342-C353, 2013.

 

Daisuke Oikawa, Akira Kitamura, Masataka Kinjo, Takao Iwawaki* "Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β" PLoS ONE, vol. 7, e51290 (1-10), 2012.

 

Jae-Seon So, Kyu-Yeon Hur, Margarite Tarrio, Vera Ruda, Maria Frank-Kamenetsky, Kevin Fitzgerald, Victor Koteliansky, Andrew H. Lichtman, Takao Iwawaki, Wen-Pin Yang, Laurie H. Glimcher, Ann-Hwee Lee* "Silencing of lipid metabolism genes through IRE1a-mediated mRNA decay lowers plasma lipids in mice" Cell Metab., vol. 16, 487-499, 2012.

 

Masaki Ri*, Etsu Tashiro*, Daisuke Oikawa, Satoko Shinjo, Mio Tokuda, Yumi Yokouchi, Tomoko Narita, Ayako Masaki, Asahi Ito, Jianming Ding, Shigeru Kusumoto, Takashi Ishida, Hirokazu Komatsu, Yukimasa Shiotsu, Ryuzo Ueda, Takao Iwawaki, Masaya Imoto, Shinsuke Iida "Identification of toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing" Blood Cancer J., vol. 2, e79, 2012.

 

Kyu Yeon Hur, Jae-Seon So, Vera Ruda, Maria Frank-Kamenetsky, Kevin Fitzgerald, Victor Koteliansky, Takao Iwawaki, Laurie H. Glimcher*, Ann-Hwee Lee* "IRE1α activation protects mice against acetaminophen-induced hepatotoxicity" J. Exp. Med., vol. 209, 307-318, 2012.

 

Daisuke Oikawa, Ryoko Akai, Mio Tokuda, Takao Iwawaki* "A transgenic mouse model for monitoring oxidative stress" Sci. Rep., vol. 2, no. 229, 1-8, 2012.


Takao Iwawaki*, Mio Tokuda "Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing" Biochem. Biophys. Res. Commun., vol. 413, 527-531, 2011.

 

Takahide Tohmonda, Yoshiteru Miyauchi, Rajarshi Ghosh, Masaki Yoda, Shinichi Uchikawa, Jiro Takito, Hideo Morioka, Masaya Nakamura, Takao Iwawaki, Kazuhiro Chiba, Yoshiaki Toyama, Fumihiko Urano, Keisuke Horiuchi* "The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix" EMBO Rep., vol. 12, 451-457, 2011.

 

Edward Thorp, Takao Iwawaki, Masayuki Miura, Ira Tabas* "A reporter for tracking the unfolded protein response in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression" J. Lipid Res., vol. 52, 1033-1038, 2011.

 

Yuji Miyazaki, Koichi Kaikita, Motoyoshi Endo, Eiji Horio, Mitsutoshi Miura, Kenichi Tsujita, Seiji Hokimoto, Megumi Yamamuro, Takao Iwawaki, Tomomi Gotoh, Hisao Ogawa, Yuichi Oike* "C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation" Arterioscler. Thromb. Vasc. Biol., vol. 31, 1124-1132, 2011.

 

Akira Hosoda, Atsushi Maruyama, Daisuke Oikawa, Yusuke Oshima, Yuichi Komachi, Genichi Kanai, Hidetoshi Sato, Takao Iwawaki* "Detection of ER stress in vivo by Raman spectroscopy" Biochem. Biophys. Res. Commun., vol. 405, 37-41, 2011.


Takao Iwawaki*, Ryoko Akai, Kenji Kohno "IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level." PLoS ONE, vol. 5, e13052 (1-11), 2010.

 

Hirato Tsukano, Tomomi Gotoh*, Motoyoshi Endo, Miyata Keishi, Hirokazu Tazume, Tsuyoshi Kadomatsu, Masato Yano, Takao Iwawaki, Kenji Kohno, Kimi Araki, Hiroshi Mizuta, Yuichi Oike* "The endoplasmic reticulum stress-CHOP pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques." Arterioscler. Thromb. Vasc. Biol., vol. 30, 1925-1932, 2010.

 

Daisuke Oikawa, Mio Tokuda, Akira Hosoda, Takao Iwawaki* "Identication of a consensus element recognized and cleaved by IRE1alpha." Nucleic Acid Res., vol. 38, 6265-6273, 2010.

 

Daisuke Oikawa, Ryoko Akai, Takao Iwawaki* "Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes." FEBS Lett., vol. 584, 1066-1070, 2010.

 

Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki* "Positive contribution of Erdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland." Biochem. J., vol. 425, 117-125, 2010.

 

Kazutomi Yoshiuchi, Hideaki Kaneto*, Taka-aki Matsuoka, Ryuichi Kasami, Kenji Kohno, Takao Iwawaki, Yoshihisa Nakatani, Yoshimitsu Yamasaki, Iichiro Shimomura, Munehide Matsuhisa  "Pioglitazone Reduces ER Stress in the Liver: Direct Monitoring of in vivo ER Stress Using ER Stress-activated Indicator Transgenic Mice." Endocr. J., vol. 56, 1103-1111, 2009.


Takao Iwawaki*, Ryoko Akai, Shinya Yamanaka, Kenji Kohno "Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability." Proc. Natl. Acad. Sci. USA, vol. 106, 16657-16662, 2009.

 

Mitsuhisa Tabata, Tsuyoshi Kadomatsu, Shigetomo Fukuhara, Keishi Miyata, Yasuhiro Ito, Motoyoshi Endo, Takashi Urano, Hui Juan Zhu, Hiroto Tsukano, Hirokazu Tazume, Koichi Kaikita, Kazuya Miyashita, Takao Iwawaki, Michio Shimabukuro, Kazuhiko Sakaguchi, Takaaki Ito, Naomi Nakagata, Tetsuya Yamada, Hideki Katagiri, Masato Kasuga, Yukio Ando, Hisao Ogawa, Naoki Mochizuki, Hiroshi Itoh, Toshio Suda, Yuichi Oike* "Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance." Cell Metab., vol. 10, 178-188, 2009.

 

Daisuke Oikawa, Yukio Kimata, Kenji Kohno, Takao Iwawaki* "Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins." Exp. Cell Res., vol. 315, 2496-2504, 2009.

 

Kota Yanagitani, Yusuke Imagawa, Takao Iwawaki, Akira Hosoda, Michiko Saito, Yukio Kimata, Kenji Kohno*. "Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA." Mol. Cell, vol. 34, 191-200, 2009.

 

Fernando Abarzua, Yuji Kashiwakura*, Munenori Takaoka, Masami Watanabe, Kazuhiko Ochiai, Masakiyo Sakaguchi, Takao Iwawaki, Ryuta Tanimoto, Yasutomo Nasu, Nam-ho Huh, Hiromi Kumon "An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis."Biochem. Biophys. Res. Commun., vol. 375, 614-618, 2008.

 

Kazutomi Yoshiuchi, Hideaki Kaneto*, Taka-aki Matsuoka, Kenji Kohno, Takao Iwawaki, Yoshihisa Nakatani, Yoshimitsu Yamasaki, Masatsugu Hori, Munehide Matsuhisa "Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice." Biochem. Biophys. Res. Commun., vol. 366, 545-550, 2008.

 

Daisuke Oikawa, Mio Tokuda, Takao Iwawaki* "Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1." Biochem. Biophys. Res. Commun., vol. 360, 122-127, 2007.


Takao Iwawaki*, Ryoko Akai “Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress indicators.” Biochem. Biophys. Res. Commun., vol. 350, 709-715, 2006.

 

Seiko Yamada, Tetsuo Yamaguchi, Akira Hosoda, Takao Iwawaki, Kenji Kohno* "Regulation of human STARD4 gene expression under endoplasmic reticulum stress." Biochem. Biophys. Res. Commun., vol. 343, 1079-1085, 2006.


Takao Iwawaki, Kenji Kohno, Masayuki Miura* "Transgenic mouse model for monitoring endoplasmic reticulumn stress in vivo." Nat. Med., vol. 10, 1013-1014, 2004 (Correspondence).


Takao Iwawaki, Ryoko Akai, Kenji Kohno, Masayuki Miura* "A transgenic mouse model for monitoring endoplasmic reticulum stress." Nat. Med., vol. 10, 98-102, 2004.

 

Shinichi Kiso*, Sumio Kawata, Shinji Tamura, Yoshiaki Inui, Yuichi Yoshida, Yoshiyuki Sawai, Shinobu Umeki, Nobuyuki Ito, Akira Yamada, Jun-Ichiro Miyagawa, Shigeki Higashiyama, Takao Iwawaki, Michiko Saito, Naoyuki Taniguchi, Yuji Matsuzawa, Kenji Kouno "Liver Regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy." Gastroenterology, vol. 124, 701-707, 2003.

 

Michiko Saito, Takao Iwawaki, Choji Taya, Hiromichi Yonekawa, Munehiro Noda, Yoshiaki Inui, Eisuke Mekada, Yukio Kimata, Akio Tsuru, Kenji Kohno* "Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice." Nat. Biotechnol., vol. 19, 746-750, 2001. (注;第二著者はこの論文において筆頭著者と同等の扱いである。)


Takao Iwawaki, Akira Hosoda, Tetsuo Okuda, Yusuke Kamigori, Chizumi Nomura-Furuwatari, Yukio Kimata, Akio Tsuru, Kenji Kohno* "Translational control by ER transmembrane kinase/ribonuclease IRE1 under ER stress." Nat. Cell Biol., vol. 3, 158-164, 2001.

 

Takao Iwawaki, Kenji Kohno, Kazuto Kobayashi* "Identification of a potential Nurr1 response element that activates the tyrosine hydroxylase gene promoter in cultured cells." Biochem. Biophys. Res. Commun., vol. 274, 590-595, 2000.

 

(*はcorresponding author)

岩脇 隆夫

講師

先端医学・生命科学研究チーム

医学・生命科学分野